Columbus, Ohio is 4.1 times larger than St. Louis.
Area: 694 km2 calculated
Columbus is the capital of and the largest city in the U.S. state of Ohio. It is the 15th largest city in the United States with a population of 822,553. It is the core city of the Columbus, OH Metropolitan Statistical Area, which encompasses a ten county area. Wikipedia
Area: 170 km2 calculated
St. Louis is an independent city and a major United States port in eastern Missouri. The city reaches the western banks of the Mississippi River, which forms Missouri's eastern border with Illinois. At the 2010 census, St. Wikipedia